Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages.

Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages.

Liver fibrosis results from the co-ordinated actions of myofibroblasts and macrophages, a proportion of which are of bone marrow origin. The functional effect of such bone marrow-derived cells on liver fibrosis is unclear. We examine whether changing bone marrow genotype can down-regulate the liver&...

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Bibliographic Details
Main Authors: Yiannis N Kallis, Christopher J Scotton, Alison C Mackinnon, Robert D Goldin, Nicholas A Wright, John P Iredale, Rachel C Chambers, Stuart J Forbes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3903514?pdf=render

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http://europepmc.org/articles/PMC3903514?pdf=render

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