The downregulated membrane expression of CD18 in CD34+ cells defines a primitive population of human hematopoietic stem cells

The downregulated membrane expression of CD18 in CD34+ cells defines a primitive population of human hematopoietic stem cells

Abstract Background CD18 is the common beta subunit of β2 integrins, which are expressed on hematopoietic cells. β2 integrins are essential for cell adhesion and leukocyte trafficking. Methods Here we have analyzed the expression of CD18 in different subsets of human hematopoietic stem and progenito...

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Bibliographic Details
Main Authors: Cristina Mesa-Núñez, Diego Leon-Rico, Montserrat Aldea, Carlos Damián, Raquel Sanchez-Baltasar, Rebeca Sanchez, Omaira Alberquilla, José Carlos Segovia, Juan Antonio Bueren, Elena Almarza
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Stem Cell Research & Therapy
Subjects:
Hematopoietic stem cells
CD18
Integrins
Long-term repopulating cells
Online Access:http://link.springer.com/article/10.1186/s13287-020-01672-0

Internet

http://link.springer.com/article/10.1186/s13287-020-01672-0

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