Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation

Microglia and astrocytes become reactive following traumatic brain injury (TBI). However, the coordination of this reactivity and its relation to pathophysiology are unclear. Here, we show that microglia transform astrocytes into a neuroprotective phenotype via downregulation of the P2Y1 purinergic...

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Bibliographic Details
Main Authors: Youichi Shinozaki, Keisuke Shibata, Keitaro Yoshida, Eiji Shigetomi, Christian Gachet, Kazuhiro Ikenaka, Kenji F. Tanaka, Schuichi Koizumi
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
astrocytes
astrocyte scar
ATP
cytokines
microglia
neuroprotection
purinergic signal
P2Y1 receptors
traumatic brain injury
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717305417

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http://www.sciencedirect.com/science/article/pii/S2211124717305417

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