Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence.

Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence.

Alcohol consumption is known to lead to gene expression changes in the brain. After performing weighted gene co-expression network analyses (WGCNA) on genome-wide mRNA and microRNA (miRNA) expression in Nucleus Accumbens (NAc) of subjects with alcohol dependence (AD; N = 18) and of matched controls...

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Bibliographic Details
Main Authors: Mohammed Mamdani, Vernell Williamson, Gowon O McMichael, Tana Blevins, Fazil Aliev, Amy Adkins, Laura Hack, Tim Bigdeli, Andrew D van der Vaart, Bradley Todd Web, Silviu-Alin Bacanu, Gursharan Kalsi, COGA Consortium, Kenneth S Kendler, Michael F Miles, Danielle Dick, Brien P Riley, Catherine Dumur, Vladimir I Vladimirov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0137671

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https://doi.org/10.1371/journal.pone.0137671

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