Domatinostat favors the immunotherapy response by modulating the tumor immune microenvironment (TIME)

Domatinostat favors the immunotherapy response by modulating the tumor immune microenvironment (TIME)

Abstract Background The efficacy of PD-(L)1 blockade depends on the composition of the tumor immune microenvironment (TIME) and is generally higher in tumors with pre-existing cytotoxic T cells (CTL) than in those with low CTL numbers. Nonetheless, a significant proportion of patients with pre-exist...

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Bibliographic Details
Main Authors: Anne Catherine Bretz, Ulrike Parnitzke, Kerstin Kronthaler, Tobias Dreker, René Bartz, Frank Hermann, Astrid Ammendola, Tanja Wulff, Svetlana Hamm
Format: Article
Language:English
Published: BMJ Publishing Group 2019-11-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
Domatinostat
HDAC
Immunotherapy
Checkpoint inhibitor
Tumor immune microenvironment
IFN-γ signature
Online Access:http://link.springer.com/article/10.1186/s40425-019-0745-3

Internet

http://link.springer.com/article/10.1186/s40425-019-0745-3

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