Astrocytic and neuronal accumulation of elevated extracellular K+ with a 2/3 K+/Na+ flux ratio - consequences for energy metabolism, osmolarity and higher brain function

Astrocytic and neuronal accumulation of elevated extracellular K+ with a 2/3 K+/Na+ flux ratio - consequences for energy metabolism, osmolarity and higher brain function

Brain excitation increases neuronal Na+ concentration by 2 major mechanisms: i) Na+influx caused by glutamatergic synaptic activity; and ii) action-potential-mediateddepolarization by Na+ influx followed by repolarizating K+ efflux, increasingextracellular K+ concentration. This review deals mainly...

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Bibliographic Details
Main Authors: Leif eHertz, Junnan eXu, Dan eSong, Enzhi eYan, Li eGu, Liang ePeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Computational Neuroscience
Subjects:
Energy Metabolism
Neuron
astrocyte
Na+/K+-ATPase
Astrocyte；
Kir channel
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncom.2013.00114/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncom.2013.00114/full

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