Mechanisms regulating PD-L1 expression on tumor and immune cells

Mechanisms regulating PD-L1 expression on tumor and immune cells

Abstract Background The PD-1/PD-L1 checkpoint is a central mediator of immunosuppression in the tumor immune microenvironment (TME) and is primarily associated with IFN-g signaling. To characterize other factors regulating PD-L1 expression on tumor and/or immune cells, we investigated TME-resident c...

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Bibliographic Details
Main Authors: Shuming Chen, George A. Crabill, Theresa S. Pritchard, Tracee L. McMiller, Ping Wei, Drew M. Pardoll, Fan Pan, Suzanne L. Topalian
Format: Article
Language:English
Published: BMJ Publishing Group 2019-11-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
PD-L1
Cytokines
Interferon gamma
Interleukins
Tumor microenvironment
Transcription factors
Online Access:http://link.springer.com/article/10.1186/s40425-019-0770-2

Internet

http://link.springer.com/article/10.1186/s40425-019-0770-2

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