The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function

The Soluble Adenylyl Cyclase Inhibitor LRE1 Prevents Hepatic Ischemia/Reperfusion Damage Through Improvement of Mitochondrial Function

Hepatic ischemia/reperfusion (I/R) injury is a leading cause of organ dysfunction and failure in numerous pathological and surgical settings. At the core of this issue lies mitochondrial dysfunction. Hence, strategies that prime mitochondria towards damage resilience might prove applicable in a clin...

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Bibliographic Details
Main Authors: João S. Teodoro, João A. Amorim, Ivo F. Machado, Ana C. Castela, Clemens Steegborn, David A. Sinclair, Anabela P. Rolo, Carlos M. Palmeira
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
mitochondria
ischemia/reperfusion
liver
soluble adenylyl cyclase
LRE1
sirtuin 3
Online Access:https://www.mdpi.com/1422-0067/21/14/4896

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https://www.mdpi.com/1422-0067/21/14/4896

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