Blockade of the action of nitric oxide in human septic shock increases systemic vascular resistance and has detrimental effects on pulmonary function after a short infusion of methylene blue

Blockade of the action of nitric oxide in human septic shock increases systemic vascular resistance and has detrimental effects on pulmonary function after a short infusion of methylene blue

To investigate the role of nitric oxide in human sepsis, ten patients with severe septic shock requiring vasoactive drug therapy and mechanical ventilation were enrolled in a prospective, open, non-randomized clinical trial to study the acute effects of methylene blue, an inhibitor of guanylate cycl...

Full description

Bibliographic Details
Main Authors: R. Weingartner, E. Oliveira, E.S. Oliveira, U.L. Sant'Anna, R.P. Oliveira, L.A. Azambuja, G. Friedman
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 1999-12-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
vasodilation
myocardial depression
septic shock
methylene blue
nitric oxide
guanylate cyclase
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200009

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200009

Similar Items