Simultaneous inhibition of FXR and TGR5 exacerbates atherosclerotic formation

Simultaneous inhibition of FXR and TGR5 exacerbates atherosclerotic formation

Simultaneous activation of bile acid receptors farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5) by INT-767 significantly reduces atherosclerotic formation. In this study, we investigated the effect of simultaneous inactivation of these bile acid receptors in atheroscleros...

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Bibliographic Details
Main Authors: Shinobu Miyazaki-Anzai, Masashi Masuda, Shohei Kohno, Moshe Levi, Yuji Shiozaki, Audrey L. Keenan, Makoto Miyazaki
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Journal of Lipid Research
Subjects:
atherosclerosis
bile acid
inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520335392

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http://www.sciencedirect.com/science/article/pii/S0022227520335392

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