Hepatic SIRT3 Upregulation in Response to Chronic Alcohol Consumption Contributes to Alcoholic Liver Disease in Mice

Hepatic SIRT3 Upregulation in Response to Chronic Alcohol Consumption Contributes to Alcoholic Liver Disease in Mice

BackgroundAlcoholic liver disease (ALD) is a type of chronic liver disease caused by chronic ethanol overconsumption. The pathogenesis of ALD is complex and there is no effective clinical treatment thus far. SIRT3 is an NAD+-dependent deacetylase primarily located inside mitochondria, and reports on...

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Bibliographic Details
Main Authors: Yue Ma, Hui Chai, Qinchao Ding, Qianyu Qian, Zhaoyuan Yan, Bin Ding, Xiaobing Dou, Songtao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Physiology
Subjects:
sirtuin 3
autophagy
liver injury
hepatotoxicity
ALD
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01042/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.01042/full

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