Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α

Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α

Alzheimer’s disease (AD) is tightly linked to oxidative stress since amyloid beta-peptide (Aβ) aggregates generate free radicals. Moreover, the aggregation of Aβ is increased by oxidative stress, and the neurotoxicity induced by the oligomers and fibrils is in part mediated by free radicals. Interes...

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Bibliographic Details
Main Authors: Pol Picón-Pagès, Daniela A. Gutiérrez, Alejandro Barranco-Almohalla, Giulia Crepin, Marta Tajes, Gerard ILL-Raga, Francesc X. Guix, Silvia Menéndez, Montserrat Arumí-Uría, Rubén Vicente, Alejandra R. Álvarez, Francisco J. Muñoz
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2020/2739459

Internet

http://dx.doi.org/10.1155/2020/2739459

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