Dietary Glycotoxins, Advanced Glycation End Products, Inhibit Cell Proliferation and Progesterone Secretion in Ovarian Granulosa Cells and Mimic PCOS-Like Symptoms

Dietary Glycotoxins, Advanced Glycation End Products, Inhibit Cell Proliferation and Progesterone Secretion in Ovarian Granulosa Cells and Mimic PCOS-Like Symptoms

Women with polycystic ovary syndrome (PCOS) have been reported to have an elevated serum advanced glycation end product (AGE) level. However, the effect of AGEs on the pathophysiological ovarian granulosa cells of PCOS is still unclear. In this study, five indented BSA-derived AGE products were used...

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Bibliographic Details
Main Authors: Po-Han Lin, Chih-Chao Chang, Kun-Hsuan Wu, Chun-Kuang Shih, Wenchang Chiang, Hsin-Yuan Chen, Yin-Hwa Shih, Kei-Lee Wang, Yong-Han Hong, Tzong-Ming Shieh, Shih-Min Hsia
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Biomolecules
Subjects:
Polycystic ovary syndrome (PCOS)
ovarian granulosa cells
advanced glycation end products (AGEs)
dehydroepiandrosterone (DHEA)
hyperandrogenism
Online Access:https://www.mdpi.com/2218-273X/9/8/327

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https://www.mdpi.com/2218-273X/9/8/327

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