Determination of serum levels of imatinib mesylate in patients with chronic myeloid leukemia: validation and application of a new analytical method to monitor treatment compliance

Determination of serum levels of imatinib mesylate in patients with chronic myeloid leukemia: validation and application of a new analytical method to monitor treatment compliance

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OBJECTIVE: The goal of this study was to monitor imatinib mesylate therapeutically in the Tumor Biology Laboratory, Department of Hematology and Hemotherapy, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP). A simple and sensitive method to quantify imatinib and its meta...

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Bibliographic Details
Main Authors: Vinícius Marcondes Rezende, Ariane Julio Rivellis, Melissa Medrano Gomes, Felipe Augusto Dörr, Mafalda Megumi Yoshinaga Novaes, Luciana Nardinelli, Ariel Lais de Lima Costa, Dalton de Alencar Fisher Chamone, Israel Bendit
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Revista Brasileira de Hematologia e Hemoterapia
Subjects:
Leukemia
myelogenous
chronic
BCR-ABL positive
Mass spectrometry
Chromatography
high pressure liquid
Pyrimidines
Antineoplastic agents
Therapeutic drug monitoring
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000200011

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000200011

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