Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in SepsisResearch in context

Inactivation of the tyrosine phosphatase SHP-2 drives vascular dysfunction in SepsisResearch in context

Background: Sepsis, the most severe form of infection, involves endothelial dysfunction which contributes to organ failure. To improve therapeutic prospects, elucidation of molecular mechanisms underlying endothelial vascular failure is of essence. Methods: Polymicrobial contamination induced sepsis...

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Bibliographic Details
Main Authors: Yvonn Heun, Joachim Pircher, Thomas Czermak, Philipp Bluem, Georg Hupel, Monica Bohmer, Bjoern F. Kraemer, Kristin Pogoda, Alexander Pfeifer, Markus Woernle, Andrea Ribeiro, Max Hübner, Simone Kreth, Ralf A. Claus, Sebastian Weis, Luisa Ungelenk, Florian Krötz, Ulrich Pohl, Hanna Mannell
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419301744

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http://www.sciencedirect.com/science/article/pii/S2352396419301744

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