T-Type Ca2+ Channel Blocker, KYS05090 Induces Autophagy and Apoptosis in A549 Cells through Inhibiting Glucose Uptake

T-Type Ca2+ Channel Blocker, KYS05090 Induces Autophagy and Apoptosis in A549 Cells through Inhibiting Glucose Uptake

It has been reported that [3-(1,1'-biphenyl-4-yl)-2-(1-methyl-5-dimethylamino-pentylamino)-3,4-dihydroquinazolin-4-yl]-N-benzylacetamide 2hydrochloride (KYS05090), a selective T-type Ca2+ channel blocker, reduces tumor volume and weight in the A549 xenograft model, but the molecular mechanism o...

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Bibliographic Details
Main Authors: Hong-Kun Rim, Sehyeon Cho, Dong-Hyun Shin, Kyung-Sook Chung, Young-Wuk Cho, Jung-Hye Choi, Jae Yeol Lee, Kyung-Tae Lee
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Molecules
Subjects:
T-type Ca2+ channel
glucose
autophagy
apoptosis
reactive oxygen species
Online Access:http://www.mdpi.com/1420-3049/19/7/9864

Internet

http://www.mdpi.com/1420-3049/19/7/9864

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