Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

Abstract Background Converging evidence suggests a role for microglia-mediated neuroinflammation in Parkinson’s disease (PD). Animal models of PD can serve as a platform to investigate the role of neuroinflammation in degeneration in PD. However, due to features of the previously available PD models...

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Bibliographic Details
Main Authors: Megan F. Duffy, Timothy J. Collier, Joseph R. Patterson, Christopher J. Kemp, Kelvin C. Luk, Malú G. Tansey, Katrina L. Paumier, Nicholas M. Kanaan, D. Luke Fischer, Nicole K. Polinski, Olivia L. Barth, Jacob W. Howe, Nishant N. Vaikath, Nour K. Majbour, Omar M. A. El-Agnaf, Caryl E. Sortwell
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Parkinson’s disease
Animal models
Synucleinopathy
Microglia
Major-histocompatibility complex-II
Online Access:http://link.springer.com/article/10.1186/s12974-018-1171-z

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http://link.springer.com/article/10.1186/s12974-018-1171-z

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