Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function

Mouse strain differences in SSRI sensitivity correlate with serotonin transporter binding and function

Abstract Selective serotonin reuptake inhibitors (SSRIs) bind 5-HT transporters, leading to the accumulation of 5-HT and amelioration of depression. Although different mouse strains show varying sensitivity to SSRIs in mouse models of depression, the underlying mechanism of these strain differences...

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Bibliographic Details
Main Authors: Zeng-liang Jin, Xiao-Fei Chen, Yu-hua Ran, Xiao-rong Li, Jie Xiong, Yuan-yuan Zheng, Na-na Gao, Yun-Feng Li
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-08953-4

Internet

https://doi.org/10.1038/s41598-017-08953-4

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