Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes.

Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes.

We describe the detailed structural investigation of nidogen-1/laminin γ1 complexes using full-length nidogen-1 and a number of laminin γ1 variants. The interactions of nidogen-1 with laminin variants γ1 LEb2-4, γ1 LEb2-4 N836D, γ1 short arm, and γ1 short arm N836D were investigated by applying a co...

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Bibliographic Details
Main Authors: Philip Lössl, Knut Kölbel, Dirk Tänzler, David Nannemann, Christian H Ihling, Manuel V Keller, Marian Schneider, Frank Zaucke, Jens Meiler, Andrea Sinz
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4227867?pdf=render

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http://europepmc.org/articles/PMC4227867?pdf=render

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