Insulin-like growth factor-1 overexpression increases long-term survival of posttrauma-born hippocampal neurons while inhibiting ectopic migration following traumatic brain injury

Insulin-like growth factor-1 overexpression increases long-term survival of posttrauma-born hippocampal neurons while inhibiting ectopic migration following traumatic brain injury

Abstract Cellular damage associated with traumatic brain injury (TBI) manifests in motor and cognitive dysfunction following injury. Experimental models of TBI reveal cell death in the granule cell layer (GCL) of the hippocampal dentate gyrus acutely after injury. Adult-born neurons residing in the...

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Bibliographic Details
Main Authors: Erica L. Littlejohn, Danielle Scott, Kathryn E. Saatman
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Acta Neuropathologica Communications
Subjects:
Cognitive flexibility
Controlled cortical impact
Dentate gyrus
Gliogenesis
Granule cell layer
Neurogenesis
Online Access:http://link.springer.com/article/10.1186/s40478-020-00925-6

Internet

http://link.springer.com/article/10.1186/s40478-020-00925-6

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