Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis

Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis

Contactin-associated protein-like 2 (Caspr2), also known as CNTNAP2, is a cell adhesion molecule that clusters voltage-gated potassium channels (Kv1.1/1.2) at the juxtaparanodes of myelinated axons and may regulate axonal excitability. As a component of the Kv1 complex, Caspr2 has been identified as...

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Bibliographic Details
Main Authors: Delphine ePinatel, Bruno eHivert, José eBoucraut, Margaux eSaint-Martin, Veronique eRogemond, Lida eZoupi, Domna eKaragogeos, Jerome eHonnorat, Catherine eFaivre-Sarrailh
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Autoimmunity
Cell Adhesion
Contactin 2
Interneurons
Voltage-gated potassium channels
CNTNAP2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00265/full

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http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00265/full

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