Advanced glycation end-products induce apoptosis in pancreatic islet endothelial cells via NF-κB-activated cyclooxygenase-2/prostaglandin E2 up-regulation.

Advanced glycation end-products induce apoptosis in pancreatic islet endothelial cells via NF-κB-activated cyclooxygenase-2/prostaglandin E2 up-regulation.

Microvascular complications eventually affect nearly all patients with diabetes. Advanced glycation end-products (AGEs) resulting from hyperglycemia are a complex and heterogeneous group of compounds that accumulate in the plasma and tissues in diabetic patients. They are responsible for both endoth...

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Bibliographic Details
Main Authors: Kuo-Cheng Lan, Chen-Yuan Chiu, Chia-Wei Kao, Kuo-How Huang, Ching-Chia Wang, Kuo-Tong Huang, Keh-Sung Tsai, Meei-Ling Sheu, Shing Hwa Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4405342?pdf=render

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http://europepmc.org/articles/PMC4405342?pdf=render

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