Epitopes of MUC1 Tandem Repeats in Cancer as Revealed by Antibody Crystallography: Toward Glycopeptide Signature-Guided Therapy

Epitopes of MUC1 Tandem Repeats in Cancer as Revealed by Antibody Crystallography: Toward Glycopeptide Signature-Guided Therapy

Abnormally O-glycosylated MUC1 tandem repeat glycopeptide epitopes expressed by multiple types of cancer have long been attractive targets for therapy in the race against genetic mutations of tumor cells. Glycopeptide signature-guided therapy might be a more promising avenue than mutation signature-...

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Bibliographic Details
Main Authors: Dapeng Zhou, Lan Xu, Wei Huang, Torsten Tonn
Format: Article
Language:English
Published: MDPI AG 2018-05-01
Series:Molecules
Subjects:
MUC1
tandem repeat
antibodies
glycopeptide
co-crystal
Online Access:http://www.mdpi.com/1420-3049/23/6/1326

Internet

http://www.mdpi.com/1420-3049/23/6/1326

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