Diffusion basis spectrum imaging measures anti-inflammatory and neuroprotective effects of fingolimod on murine optic neuritis

Diffusion basis spectrum imaging measures anti-inflammatory and neuroprotective effects of fingolimod on murine optic neuritis

Objective: To prospectively determine whether diffusion basis spectrum imaging (DBSI) detects, differentiates and quantitates coexisting inflammation, demyelination, axonal injury and axon loss in mice with optic neuritis (ON) due to experimental autoimmune encephalomyelitis (EAE), and to determine...

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Bibliographic Details
Main Authors: Ruimeng Yang, Tsen-Hsuan Lin, Jie Zhan, Shengsheng Lai, Chunyu Song, Peng Sun, Zezhong Ye, Michael Wallendorf, Ajit George, Anne H. Cross, Sheng-Kwei Song
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:NeuroImage: Clinical
Subjects:
Optic neuritis
Demyelination
Multiple sclerosis, diffusion basis spectrum imaging
Axonal loss
Fingolimod
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158221001765

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http://www.sciencedirect.com/science/article/pii/S2213158221001765

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