Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms

Objective. This study was designed to investigate whether leptin modifies angiotensin (Ang) II-induced proliferation of aortic vascular smooth muscle cells (VSMCs) from 10-week-old male Wistar and spontaneously hypertensive rats (SHR), and the possible role of nitric oxide (NO). Methods. NO and NO s...

Full description

Bibliographic Details
Main Authors: Amaia Rodríguez, Javier Gómez-Ambrosi, Victoria Catalán, Ana Fortuño, Gema Frühbeck
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2010/105489