Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms

Leptin Inhibits the Proliferation of Vascular Smooth Muscle Cells Induced by Angiotensin II through Nitric Oxide-Dependent Mechanisms

Objective. This study was designed to investigate whether leptin modifies angiotensin (Ang) II-induced proliferation of aortic vascular smooth muscle cells (VSMCs) from 10-week-old male Wistar and spontaneously hypertensive rats (SHR), and the possible role of nitric oxide (NO). Methods. NO and NO s...

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Bibliographic Details
Main Authors:	Amaia Rodríguez, Javier Gómez-Ambrosi, Victoria Catalán, Ana Fortuño, Gema Frühbeck
Format:	Article
Language:	English
Published:	Hindawi Limited 2010-01-01
Series:	Mediators of Inflammation
Online Access:	http://dx.doi.org/10.1155/2010/105489

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