Fibronectin inhibitor pUR4 attenuates tumor necrosis factor α–induced endothelial hyperpermeability by modulating β1 integrin activation

Fibronectin inhibitor pUR4 attenuates tumor necrosis factor α–induced endothelial hyperpermeability by modulating β1 integrin activation

Abstract Background The blood–spinal cord barrier (BSCB) is composed of a monolayer of endothelium linked with tight junctions and extracellular matrix (ECM)-rich basement membranes and is surrounded by astrocyte foot processes. Endothelial permeability is regulated by interaction between endothelia...

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Bibliographic Details
Main Authors: Ting-Hein Lee, Sung-Tsang Hsieh, Hou-Yu Chiang
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Journal of Biomedical Science
Subjects:
Endothelial permeability
Fibronectin
β1 integrin
Stress fiber
Online Access:http://link.springer.com/article/10.1186/s12929-019-0529-6

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http://link.springer.com/article/10.1186/s12929-019-0529-6

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