Priming as a strategy to overcome detrimental pH effects on cells for intervertebral disc regeneration

Disc disease is characterised by degeneration of the nucleus pulposus (NP), the central gelatinous tissue of the intervertebral disc (IVD). As degeneration progresses, the microenvironment of the IVD becomes more hostile (i.e. decrease in oxygen, glucose and pH), providing a significant challenge fo...

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Bibliographic Details
Main Authors: J Gansau, CT Buckley
Format: Article
Language:English
Published: AO Research Institute Davos 2021-02-01
Series:European Cells & Materials
Subjects:
Online Access:https://www.ecmjournal.org/papers/vol041/pdf/v041a11.pdf