Prolonged ursodeoxycholic acid administration reduces acute ischaemia-induced arrhythmias in adult rat hearts

Abstract Acute myocardial ischaemia and reperfusion (I–R) are major causes of ventricular arrhythmias in patients with a history of coronary artery disease. Ursodeoxycholic acid (UDCA) has previously been shown to be antiarrhythmic in fetal hearts. This study was performed to investigate if UDCA pro...

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Bibliographic Details
Main Authors: Elisa Ferraro, Lidia Pozhidaeva, David S. Pitcher, Catherine Mansfield, Jia Han Benjamin Koh, Catherine Williamson, Oleg Aslanidi, Julia Gorelik, Fu Siong Ng
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-72016-4