Glial Cell Line-Derived Neurotrophic Factor Partially Ameliorates Motor Symptoms without Slowing Neurodegeneration in Mice with Respiratory Chain-Deficient Dopamine Neurons

Glial Cell Line-Derived Neurotrophic Factor Partially Ameliorates Motor Symptoms without Slowing Neurodegeneration in Mice with Respiratory Chain-Deficient Dopamine Neurons

Degeneration of midbrain dopamine neurons causes the striatal dopamine deficiency responsible for the hallmark motor symptoms of Parkinson's disease (PD). Intraparenchymal delivery of neurotrophic factors, such as glial cell line-derived neurotrophic factor (GDNF), is a possible future therapeu...

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Bibliographic Details
Main Authors: Fredrik H. Sterky, Karin Pernold, Brandon K. Harvey, Eva Lindqvist, Barry J. Hoffer, Lars Olson
Format: Article
Language:English
Published: SAGE Publishing 2013-09-01
Series:Cell Transplantation
Online Access:https://doi.org/10.3727/096368912X657693

Internet

https://doi.org/10.3727/096368912X657693

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