The effect of spike mutations on SARS-CoV-2 neutralization

The effect of spike mutations on SARS-CoV-2 neutralization

Summary: Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the viral entry protein, spike. Because new SARS-CoV-2 variants are emerging rapidly, as exemplified by the B.1.1.7,...

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Bibliographic Details
Main Authors: Chloe Rees-Spear, Luke Muir, Sarah A. Griffith, Judith Heaney, Yoann Aldon, Jonne L. Snitselaar, Peter Thomas, Carl Graham, Jeffrey Seow, Nayung Lee, Annachiara Rosa, Chloe Roustan, Catherine F. Houlihan, Rogier W. Sanders, Ravindra K. Gupta, Peter Cherepanov, Hans J. Stauss, Eleni Nastouli, Katie J. Doores, Marit J. van Gils, Laura E. McCoy
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Cell Reports
Subjects:
SARS-CoV-2
neutralization
antibodies
serology
immune escape
variant
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002047

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http://www.sciencedirect.com/science/article/pii/S2211124721002047

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