Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis

Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis

Abstract RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclear. Here we generated RAP1-deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cel...

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Bibliographic Details
Main Authors: Xing Zhang, Zunpeng Liu, Xiaoqian Liu, Si Wang, Yiyuan Zhang, Xiaojuan He, Shuhui Sun, Shuai Ma, Ng Shyh-Chang, Feng Liu, Qiang Wang, Xiaoqun Wang, Lin Liu, Weiqi Zhang, Moshi Song, Guang-Hui Liu, Jing Qu
Format: Article
Language:English
Published: SpringerOpen 2019-02-01
Series:Protein & Cell
Subjects:
RAP1
stem cell
telomere
RELN
methylation
Online Access:http://link.springer.com/article/10.1007/s13238-019-0610-7

Internet

http://link.springer.com/article/10.1007/s13238-019-0610-7

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