Enrichment differentiation of human induced pluripotent stem cells into sinoatrial node-like cells by combined modulation of BMP, FGF, and RA signaling pathways

Enrichment differentiation of human induced pluripotent stem cells into sinoatrial node-like cells by combined modulation of BMP, FGF, and RA signaling pathways

Abstract Background Biological pacemakers derived from pluripotent stem cell (PSC) have been considered as a potential therapeutic surrogate for sick sinus syndrome. So it is essential to develop highly efficient strategies for enrichment of sinoatrial node-like cells (SANLCs) as seed cells for biol...

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Bibliographic Details
Main Authors: Feng Liu, Yibing Fang, Xiaojie Hou, Ying Yan, Haiying Xiao, Dongchuan Zuo, Jing Wen, Linli Wang, Zhichao Zhou, Xitong Dang, Rui Zhou, Bin Liao
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Stem Cell Research & Therapy
Subjects:
Human induced pluripotent stem cell (hiPSC)
Sinus atrial node-like cell (SANLC)
Bone morphogenetic protein (BMP) signaling
Fibroblast growth factor (FGF) signaling
Retinoic acid (RA) signaling
Online Access:http://link.springer.com/article/10.1186/s13287-020-01794-5

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http://link.springer.com/article/10.1186/s13287-020-01794-5

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