Genetic Variability of Human Cytomegalovirus Clinical Isolates Correlates With Altered Expression of Natural Killer Cell-Activating Ligands and IFN-γ

Genetic Variability of Human Cytomegalovirus Clinical Isolates Correlates With Altered Expression of Natural Killer Cell-Activating Ligands and IFN-γ

Human cytomegalovirus (HCMV) infection often leads to systemic disease in immunodeficient patients and congenitally infected children. Despite its clinical significance, the exact mechanisms contributing to HCMV pathogenesis and clinical outcomes have yet to be determined. One of such mechanisms inv...

Full description

Bibliographic Details
Main Authors: Ganna Galitska, Alessandra Coscia, Diego Forni, Lars Steinbrueck, Simone De Meo, Matteo Biolatti, Marco De Andrea, Rachele Cagliani, Agata Leone, Enrico Bertino, Thomas Schulz, Angela Santoni, Santo Landolfo, Manuela Sironi, Cristina Cerboni, Valentina Dell’Oste
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
human cytomegalovirus (HCMV)
innate immunity
congenital infection
next generation sequencing
genetic variability
multiple-strain infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.532484/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.532484/full

Similar Items