Histone H2A variants alpha1-extension helix directs RNF168-mediated ubiquitination
Histone ubiquitination plays a critical role in the DNA damage response pathway. Here the authors reveal how RNF168 ubiquitinates the H2A family including noncanonical variants, H2AZ and macroH2A1/2, at the divergent N-terminal tail lysine residue.
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-05-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-16307-4 |