Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes

Icariin Ameliorates Palmitate-Induced Insulin Resistance Through Reducing Thioredoxin-Interacting Protein (TXNIP) and Suppressing ER Stress in C2C12 Myotubes

Both thioredoxin-interacting protein (TXNIP) and endoplasmic reticulum (ER) stress are implicated in skeletal muscle insulin resistance. Icariin has been found to mimic insulin action in normal skeletal muscle C2C12 cells and display anti-diabetic properties in diet-induced obese mice. However, the...

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Bibliographic Details
Main Authors: Mingxin Li, Yemin Zhang, Yingkang Cao, Deling Zhang, Le Liu, Yanghongyun Guo, Changhua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
icariin
insulin resistance
TXNIP
proteasome
skeletal muscle cells
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01180/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01180/full

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