In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells

In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells

On murine T cells, GPI-anchored ADP-ribosyltransferase 2.2 (ARTC2.2) ADP-ribosylates the P2X7 ion channel at arginine 125 in response to nicotinamide adenine dinucleotide (NAD+) released during cell preparation. We have previously shown that chronic gating of P2X7 by ADP-ribosylation reduces the vit...

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Bibliographic Details
Main Authors: Björn Rissiek, Marco Lukowiak, Friederike Raczkowski, Tim Magnus, Hans-Willi Mittrücker, Friedrich Koch-Nolte
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
ADP-ribosylation
P2X7
tissue-resident memory T cells
nanobodies
ARTC2.2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01580/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01580/full

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