Integrative genetic characterization and phenotype correlations in pheochromocytoma and paraganglioma tumours.

Integrative genetic characterization and phenotype correlations in pheochromocytoma and paraganglioma tumours.

BACKGROUND: About 60% of Pheochromocytoma (PCC) and Paraganglioma (PGL) patients have either germline or somatic mutations in one of the 12 proposed disease causing genes; SDHA, SDHB, SDHC, SDHD, SDHAF2, VHL, EPAS1, RET, NF1, TMEM127, MAX and H-RAS. Selective screening for germline mutations is rout...

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Bibliographic Details
Main Authors: Joakim Crona, Margareta Nordling, Rajani Maharjan, Dan Granberg, Peter Stålberg, Per Hellman, Peyman Björklund
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3899286?pdf=render

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http://europepmc.org/articles/PMC3899286?pdf=render

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