The Effect and Mechanism of Celecoxib in Hypoxia-Induced Survivin Up-Regulation in HUVECs

The Effect and Mechanism of Celecoxib in Hypoxia-Induced Survivin Up-Regulation in HUVECs

Background/Aims: To investigate the roles of hypoxia-inducible factor 1α (HIF-1α), cyclooxygenase-2 (Cox-2) and its product, Prostaglandin E2 (PGE2), in the mechanisms underlying hypoxia-induced survivin expression in human umbilical vein endothelial cells (HUVECs) and to examine the effect of celec...

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Bibliographic Details
Main Authors: Ning-ning Liu, Ning Zhao, Na Cai
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-09-01
Series:Cellular Physiology and Biochemistry
Subjects:
Cyclooxygenase-2
Survivin
Hypoxia inducible factor-1α
Human umbilical vein endothelial cells
Online Access:http://www.karger.com/Article/FullText/430225

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http://www.karger.com/Article/FullText/430225

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