Predicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles

Predicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles

We examined the performance of methylation scores (MS) and polygenic scores (PGS) for birth weight, BMI, prenatal maternal smoking exposure, and smoking status to assess the extent to which MS could predict these traits and exposures over and above the PGS in a multi-omics prediction model. MS may b...

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Bibliographic Details
Main Authors: Veronika V. Odintsova, Valerie Rebattu, Fiona A. Hagenbeek, René Pool, Jeffrey J. Beck, Erik A. Ehli, Catharina E. M. van Beijsterveldt, Lannie Ligthart, Gonneke Willemsen, Eco J. C. de Geus, Jouke-Jan Hottenga, Dorret I. Boomsma, Jenny van Dongen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Psychiatry
Subjects:
DNA methylation
methylation scores
polygenic scores
multi-omics prediction
birth weight
maternal smoking
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.688464/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2021.688464/full

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