Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease
Abstract With the advent of the genetic era in Parkinson’s disease (PD) research in 1997, α-synuclein was identified as an important player in a complex neurodegenerative disease that affects >10 million people worldwide. PD has been estimated to have an economic impact of $51.9 billion in the US...
Main Authors: | Luis M. A. Oliveira, Thomas Gasser, Robert Edwards, Markus Zweckstetter, Ronald Melki, Leonidas Stefanis, Hilal A. Lashuel, David Sulzer, Kostas Vekrellis, Glenda M. Halliday, Julianna J. Tomlinson, Michael Schlossmacher, Poul Henning Jensen, Julia Schulze-Hentrich, Olaf Riess, Warren D. Hirst, Omar El-Agnaf, Brit Mollenhauer, Peter Lansbury, Tiago F. Outeiro |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-07-01
|
Series: | npj Parkinson's Disease |
Online Access: | https://doi.org/10.1038/s41531-021-00203-9 |
Similar Items
-
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy.
by: Maria Xilouri, et al.
Published: (2009-01-01) -
A First Tetraplex Assay for the Simultaneous Quantification of Total α-Synuclein, Tau, β-Amyloid42 and DJ-1 in Human Cerebrospinal Fluid.
by: Niels Kruse, et al.
Published: (2016-01-01) -
Cell-produced ?-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival
by: Emmanouilidou, Evangelia, et al.
Published: (2010) -
Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein
by: Ilham Y. Abdi, et al.
Published: (2021-03-01) -
Voltage-Gated Calcium Channels and α-Synuclein: Implications in Parkinson’s Disease
by: Emmanouela Leandrou, et al.
Published: (2019-10-01)