Pharmacokinetics and Pharmacodynamics of Nemonoxacin in a Neutropenic Murine Lung Infection Model Against Streptococcus Pneumoniae

Pharmacokinetics and Pharmacodynamics of Nemonoxacin in a Neutropenic Murine Lung Infection Model Against Streptococcus Pneumoniae

Nemonoxacin, a novel nonfluorinated quinolone for the treatment of community-acquired pneumonia. We reported the pharmacokinetic/pharmacodynamic (PK/PD) targets and PK/PD breakpoints of nemonoxacin against Streptococcus pneumoniae using a neutropenic murine lung infection model. Single-dose PK analy...

Full description

Bibliographic Details
Main Authors: Xin Li, Yuancheng Chen, Xiaoyong Xu, Yi Li, Yaxin Fan, Xiaofen Liu, Xingchen Bian, Hailan Wu, Xu Zhao, Meiqing Feng, Beining Guo, Jing Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
nemonoxacin
pharmacokinetics/pharmacodynamics
streptococcus pneumoniae
neutropenic murine lung infection model
breakpoint
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.658558/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.658558/full

Similar Items