PHLI-seq: constructing and visualizing cancer genomic maps in 3D by phenotype-based high-throughput laser-aided isolation and sequencing

PHLI-seq: constructing and visualizing cancer genomic maps in 3D by phenotype-based high-throughput laser-aided isolation and sequencing

Abstract Spatial mapping of genomic data to tissue context in a high-throughput and high-resolution manner has been challenging due to technical limitations. Here, we describe PHLI-seq, a novel approach that enables high-throughput isolation and genome-wide sequence analysis of single cells or small...

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Bibliographic Details
Main Authors: Sungsik Kim, Amos Chungwon Lee, Han-Byoel Lee, Jinhyun Kim, Yushin Jung, Han Suk Ryu, Yongju Lee, Sangwook Bae, Minju Lee, Kyungmin Lee, Ryong Nam Kim, Woong-Yang Park, Wonshik Han, Sunghoon Kwon
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Genome Biology
Subjects:
Tumor heterogeneity
Cell isolation
Spatially resolved sequencing
Single-cell sequencing
Breast cancer
Precision oncology
Online Access:http://link.springer.com/article/10.1186/s13059-018-1543-9

Internet

http://link.springer.com/article/10.1186/s13059-018-1543-9

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