Toll-like receptor 3 signalling up-regulates expression of the HIV co-receptor G-protein coupled receptor 15 on human CD4+ T cells.

Toll-like receptor 3 signalling up-regulates expression of the HIV co-receptor G-protein coupled receptor 15 on human CD4+ T cells.

BACKGROUND: Many HIV-2 and SIV isolates, as well as some HIV-1 strains, can use the orphan 7-transmembrane receptor GPR15 as co-receptor for efficient entry into host cells. GPR15 is expressed on central memory and effector memory CD4(+) T cells in healthy individuals and a subset of these cells is...

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Bibliographic Details
Main Authors: Miriam Kiene, Bence Rethi, Marianne Jansson, Stephanie Dillon, Eric Lee, Rebecka Lantto, Cara Wilson, Stefan Pöhlmann, Francesca Chiodi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3928197?pdf=render

Internet

http://europepmc.org/articles/PMC3928197?pdf=render

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