Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis

Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis

Summary: Cellular heterogeneity is frequently observed in cancer, but the biological significance of heterogeneous tumor clones is not well defined. Using multicolor reporters and CRISPR-Cas9 barcoding, we trace clonal dynamics in a mouse model of sarcoma. We show that primary tumor growth is associ...

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Bibliographic Details
Main Authors: Yuning J. Tang, Jianguo Huang, Hidetoshi Tsushima, Ga I. Ban, Hongyuan Zhang, Kristianne M. Oristian, Vijitha Puviindran, Nerissa Williams, Xiruo Ding, Jianhong Ou, Sin-Ho Jung, Chang-Lung Lee, Yiqun Jiao, Benny J. Chen, David G. Kirsch, Benjamin A. Alman
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719310630

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http://www.sciencedirect.com/science/article/pii/S2211124719310630

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