From Mice to Humans: An Overview of the Potentials and Limitations of Current Transgenic Mouse Models of Major Muscular Dystrophies and Congenital Myopathies

From Mice to Humans: An Overview of the Potentials and Limitations of Current Transgenic Mouse Models of Major Muscular Dystrophies and Congenital Myopathies

Muscular dystrophies are a group of more than 160 different human neuromuscular disorders characterized by a progressive deterioration of muscle mass and strength. The causes, symptoms, age of onset, severity, and progression vary depending on the exact time point of diagnosis and the entity. Congen...

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Bibliographic Details
Main Authors: Mónika Sztretye, László Szabó, Nóra Dobrosi, János Fodor, Péter Szentesi, János Almássy, Zsuzsanna É. Magyar, Beatrix Dienes, László Csernoch
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:International Journal of Molecular Sciences
Subjects:
mouse models
muscle disorders
dystrophy
dystrophinopathies
myopathy
malignant hyperthermia
Online Access:https://www.mdpi.com/1422-0067/21/23/8935

Internet

https://www.mdpi.com/1422-0067/21/23/8935

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