Alterations of GABAergic Neuron-Associated Extracellular Matrix and Synaptic Responses in Gad1-Heterozygous Mice Subjected to Prenatal Stress

Alterations of GABAergic Neuron-Associated Extracellular Matrix and Synaptic Responses in Gad1-Heterozygous Mice Subjected to Prenatal Stress

Exposure to prenatal stress (PS) and mutations in Gad1, which encodes GABA synthesizing enzyme glutamate decarboxylase (GAD) 67, are the primary risk factors for psychiatric disorders associated with abnormalities in parvalbumin (PV)-positive GABAergic interneurons in the medial prefrontal cortex (m...

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Bibliographic Details
Main Authors: Tianying Wang, Adya Saran Sinha, Tenpei Akita, Yuchio Yanagawa, Atsuo Fukuda
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Cellular Neuroscience
Subjects:
prenatal stress
Gad1 gene
perineuronal nets
dystroglycan
psychiatric disorders
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00284/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00284/full

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