Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine

Targeting the metabolic vulnerability of acute myeloid leukemia blasts with a combination of venetoclax and 8-chloro-adenosine

Abstract Background BCL‐2 inhibition through venetoclax (VEN) targets acute myeloid leukemia (AML) blast cells and leukemic stem cells (LSCs). Although VEN-containing regimens yield 60–70% clinical response rates, the vast majority of patients inevitably suffer disease relapse, likely because of the...

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Bibliographic Details
Main Authors: Ralf Buettner, Le Xuan Truong Nguyen, Corey Morales, Min-Hsuan Chen, Xiwei Wu, Lisa S. Chen, Dinh Hoa Hoang, Servando Hernandez Vargas, Vinod Pullarkat, Varsha Gandhi, Guido Marcucci, Steven T. Rosen
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Journal of Hematology & Oncology
Subjects:
Acute myeloid leukemia
Oxidative phosphorylation
Fatty acid oxidation
Nucleoside analog
Metabolism
Online Access:https://doi.org/10.1186/s13045-021-01076-4

Internet

https://doi.org/10.1186/s13045-021-01076-4

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