Laboratory Evolution Assays and Whole-Genome Sequencing for the Development and Safety Evaluation of Lactobacillus plantarum With Stable Resistance to Gentamicin

Laboratory Evolution Assays and Whole-Genome Sequencing for the Development and Safety Evaluation of Lactobacillus plantarum With Stable Resistance to Gentamicin

The goal of this work was to use laboratory evolution assays and whole-genome sequencing to develop and test the safety of a probiotic, Lactobacillus plantarum, with high-level of resistance to gentamicin. The evolution of L. plantarum was evaluated under the selective pressure from gentamicin and s...

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Bibliographic Details
Main Authors: Yushan Dong, Fuxin Zhang, Bini Wang, Jiayuan Gao, Jiangtao Zhang, Yuyu Shao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Microbiology
Subjects:
probiotic
antibiotic resistance
laboratory evolution
whole-genome sequencing
resistant gene
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01235/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01235/full

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