Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis

Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis

Abstract Background Systemic autoimmunity can be present years before clinical onset of rheumatoid arthritis (RA). Adaptive immunity is initiated in lymphoid tissue where lymph node stromal cells (LNSCs) regulate immune responses through their intimate connection with leucocytes. We postulate that m...

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Bibliographic Details
Main Authors: Janine S. Hähnlein, Reza Nadafi, Tineke de Jong, Tamara H. Ramwadhdoebe, Johanna F. Semmelink, Karen I. Maijer, IJsbrand A. Zijlstra, Mario Maas, Danielle M. Gerlag, Teunis B. H. Geijtenbeek, Paul P. Tak, Reina E. Mebius, Lisa G. M. van Baarsen
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Arthritis Research & Therapy
Subjects:
Lymph node stromal cells
Early rheumatoid arthritis
Autoimmunity
Tolerance
Immunity
Online Access:http://link.springer.com/article/10.1186/s13075-018-1529-8

Internet

http://link.springer.com/article/10.1186/s13075-018-1529-8

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